Aciclovir and CMMG

Referred to Antimicrobial Reference Laboratory, Dept of Microbiology, Southmead Hospital, Bristol BS10 5NB
 

Alternative names, keywords

Valaciclovir (prodrug form), aciclovir metabolite, 9-carboxymethoxymethylguanine.

Samples required

Clotted blood (gold cap, 5 mL tube). Smaller tubes are available for paediatric samples.

Pre dose sample and post dose sample recommended (post dose = 1h after the end of iv administration or 2h after oral administration).

CMMG monitoring requires post-dose sample only.

Test indications

May be of value in patients with renal failure and/or on ECMO, in cases of suspected neurotoxicity or suspected poor absorption, and in some patients receiving valaciclovir (prodrug form of aciclovir).

Reference range

Depends on dose regimen - interpretation is patient-specific. Discuss interpretation with Consultant Microbiologist.

For CMMG: pre dose <2.6 mg/L

Turnaround time

Referral lab quotes turnaround time of less than 3 working days*, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.

*samples are analysed on day of receipt if before 3pm, Monday to Friday.

Enquiries

Biochemistry (Referrals)