DPD deficiency

Referred to Purine Research Lab, St Thomas' Hospital, London SE1 7EH
 

Alternative names, keywords

5-fluorouracil toxicity, 5-FU toxicity, fluoropyrimidine toxicity., DPYD mutation analysis, dihydropyrimidine dehydrogenase deficiency.

Samples required

EDTA blood (purple cap/ yellow cap ring, 4 mL tube)

Test indications

Identification of patients at risk of toxic reaction to fluoropyrimidine (5-fluorouracil) therapy.

Test information

See reports for information on variants that are tested for.

Reference range

Qualitative report.

Turnaround time

Referral lab quotes turnaround time of 3 days, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.

Enquiries

Biochemistry (Referrals)