PSA

Alternative names, keywords

Prostate specific antigen

Samples required

● Clotted blood (gold cap, 5 mL tube).

Test indications

Investigation and monitoring of prostatic disease.

Test information

Should not be used for population screening - see NICE CKS 2026

Factors affecting test performance/ results

In rare cases PSA isoforms exist which may be measured differently by different PSA tests.

In rare cases, interference due to extremely high titres of antibodies to analyte-specific antibodies, streptavidin or ruthenium can occur.

Results should always be assessed in conjunction with the patient’s medical history, clinical examination and other findings.

Reference range

Age-specific PSA thresholds for people with possible symptoms of prostate cancer:

*Use clinical judgement and refer to the NICE Clinical Knowledge Summary (2026) for PSA interpretation for patients <40 yrs or >79 yrs.

Source: Suspected cancer: recognition and referral NICE guideline [NG12] Published: 23 June 2015 Last updated: 15 December 2021

Turnaround time

One working day

Enquiries

Biochemistry (Automation)