PSA

 

Alternative names, keywords

Prostate specific antigen

Samples required

Clotted blood (gold cap, 5 mL tube).

Test indications

Investigation and monitoring of prostatic disease.

Test information

Should not be used for population screening.

Factors affecting test performance/ results

In rare cases PSA isoforms exist which may be measured differently by different PSA tests.

In rare cases, interference due to extremely high titres of antibodies to analyte-specific antibodies, streptavidin or ruthenium can occur.

Results should always be assessed in conjunction with the patient’s medical history, clinical examination and other findings.

Reference range

Age-specific PSA thresholds for people with possible symptoms of prostate cancer:

Age (years)

PSA threshold (micrograms/L)

Below 40

Use clinical judgement

40 - 49

More than 2.5

50 - 59

More than 3.5

60 - 69

More than 4.5

70 - 79

More than 6.5

Above 79

Use clinical judgement

Source: Suspected cancer: recognition and referral NICE guideline [NG12] Published: 23 June 2015 Last updated: 15 December 2021

Turnaround time

One working day

Enquiries

Biochemistry (Automation)