Fabry screen

Referred to Willink Laboratory, Regional Genetics Laboratory Services, St Mary's Hospital, Manchester M13 9WL
 

Alternative names, keywords

alpha-galactosidase, galactosidase A

Samples required

EDTA blood (purple cap/ yellow cap ring, 4 mL tube) for blood spot preparation in lab, or dried blood spots.

Test indications

Screening test for Fabry disease.

Test information

Note that female patients with Fabry disease may have normal enzyme activity so are eligible for genetic testing (R335) if clinical features characteristic of Fabry disease are present. Please download the appropriate request form from the SE Genomics Hub.

Reference range

Blood spot alpha galactosidase: 6.3 - 47 pmol/punch/h
Blood spot alpha glucosidase (reference enzyme): 7.3 - 39 pmol/punch/h

Turnaround time

Referral lab quotes turnaround time of 4 weeks, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.

Enquiries

Biochemistry (Referrals)