AMH

 

Alternative names, keywords

Anti-Müllerian Hormone

Samples required

● Clotted blood (gold cap, 5 mL tube). Smaller tubes are available for paediatric samples.

Test indications

Assessment of ovarian reserve.

Investigation of disorders of sexual development.

Factors affecting test performance/ results

Biotin may interfere - samples should not be taken from patients receiving therapy with high biotin doses (i.e. > 5 mg/day) until at least 8 hours following the last biotin administration.

In rare cases, interference due to extremely high titres of antibodies to analyte-specific antibodies, streptavidin or ruthenium can occur.

Results should always be assessed in conjunction with the patient’s medical history, clinical examination and other findings.

Reference range
    AMH (pmol/L)*
Females (not taking oral contraception) 20 to 24 years 8.7 - 83.6
25 to 29 years 6.4 - 70.3
30 to 34 years 4.1 - 58.0
35 to 39 years 1.1 - 53.5
40 to 44 years 0.2 to 39.1
45 to 50 years 0.1 to 19.3

Males

   5.5 - 103
* 2.5th to 97.5th percentile

Source: Roche Cobas® AMH Plus insert, 2022-02 V 4.0

 

Use of AMH for assessment of ovarian reserve

AMH range Antral follicle count  
less than 4.9 pmol/L 0 - 7 Low responders
4.9 - 16.2 pmol/L 8 - 15 Normal responders
greater than 16.2 pmol/L > 15 High responders

 

Paediatric ranges

 

AMH (pmol/L)*
 

Males

 Females
0 to 2 days 78.1 - 606.5 < 6.8
3 to 7 days 159.6 - 1186.2
8 to 10 days 225.5 - 1391.7
11 to 20 days 161.7 - 1310.5
21 to 28 days 245.0 - 1102.4
29 to 364 days 235.5 - 1125.9 < 31.3
1 to 4 years 310.7 - 1425.3 1.3 - 43.7
5 to 7 years 238.3 - 1108.3 1.4 - 39.5
8 to 11 years 96.6 - 1131.4 2.9 - 52.8
12 to 14 years 9.4 - 331.8 3.0 - 46.6
15 to 18 years 16.8 - 130.0 2.1 - 84.1
  2.5th to 97.5th percentile

Source: Yates et al. Paediatric reference intervals for plasma anti-Müllerian hormone: comparison of data from the Roche Elecsys assay and the Beckman Coulter Access assay using the same cohort of samples. Ann Clin Biochem.2019 Sep;56(5):536-547

Turnaround time

Four working days

Enquiries

Biochemistry (Automation PRH)
 
Details