Erythropoietin

Referred to Berkshire & Surrey Pathology Services, Frimley Park Hospital NHS Foundation Trust, Portsmouth Road, Frimley, Surrey GU16 7UJ
 

Alternative names, keywords

EPO

Samples required

 Clotted blood (gold cap, 5 mL tube), bring to lab immediately.

Note change to sample requirements from 30/6/25

Samples must be separated within 2 hours of collection. Due to EPO showing a diurnal variation it is recommended that samples for serial monitoring should be taken at a consistent time of day, and ideally between 7:30 am 12 noon.

plus

EDTA blood (purple cap/ black cap ring, 4 mL tube) for FBC. Please ensure FBC is requested, as Hb is needed for erythropoietin interpretation. 

Smaller tubes are available for paediatric samples.

Test indications

 

Reference range

5.5 - 28.4 IU/L

EPO results should be interpreted in conjunction with haemoglobin results.

Anaemia:

EPO <28.4 : inappropriately low if anaemia persists.

EPO 28.4-100: appropriate if mildly anaemic but insufficient to correct severe anaemia.

EPO >100: appropriate for a Hb <100 g/L, but not if anaemia persists.

Polycythaemia:

EPO <5.5: primary polycythaemia likely.

EPO 5.5-15: cannot differentiate between primary and secondary polycythaemia.

EPO >15: secondary polycythaemia likely

Note new reference ranges from 30/6/25

 

Turnaround time

Referral lab quotes turnaround time of 5 working days, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.

Enquiries

Biochemistry (Referrals)