Metadrenalines (urine)

Alternative names, keywords

Normetadrenaline, metadrenaline, 3-methoxytyramine, metanephrines, normetanephrine

Samples required

24 hour urine collection in acidified container. Note that a single 24h collection is required; there is no need to do 3x 24h collections.

Instructions for 24h urine collection available here or on UHSussex public site.

During urine collection patients should avoid vigorous exercise, excessive nicotine and coffee intake, chilli, curry leaves, supraphysiological doses of vitamin C. Download a printable list.

Random urine for paediatrics - take to lab immediately for acidification).

Medications can affect the results (see test information below). Please list any medications on the request form.

Test indications

First line test for investigation of ?sporadic phaeochromocytoma or paraganglioma. Click for protocols for investigation of suspected sporadic phaeochromocytoma:

in primary care

in secondary care

Test information

Increased physiological levels of metadrenalines can be seen with MAO inhibitors, tricyclic anti-depressants, levodopa, SNRIs, alpha-adrenergic receptor blockers, amphetamine, ephedrine, and with significant physical or emotional stress.

Reference range

Age-related ranges apply to random paediatric samples - see report.

Turnaround time

Referral lab quotes turnaround time of 10 days, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.

Enquiries

Biochemistry (Referrals)