Neuronal antibodies

Referred to Berkshire & Surrey Pathology Services, Frimley Park Hospital Frimley Park Hospital NHS Foundation Trust, Portsmouth Road, Frimley, Surrey GU16 7UJ
 

Alternative names, keywords

Paraneoplastic antibodies, anti neuronal antibodies, antineuronal antibodies, Purkinje cell antibodies, onconeuronal abs, anti-Hu (ANNA-1), anti-Ri (ANNA-2), anti-Yo, anti-Ta (Ma2), anti-CV2/CRMP5, anti-amphiphysin, anti-Zic4, anti-SOX-1, anti-Tr, anti-Titin, anti-recoverin, anti-GAD65.

Samples required

Clotted blood (gold cap, 5 mL tube).

Please indicate any specific antibody requirements on request form.

Test indications

Investigation of suspected paraneoplastic neurological syndromes.

Test information

Immunoblotting detects anti-Hu (ANNA-1), anti-Ri (ANNA-2), anti-Yo, anti-Ta (Ma2), anti-CV2/CRMP5, anti-amphiphysin, anti-Zic4, anti-SOX-1, anti-Tr, anti-Titin, anti-Recoverin, anti-GAD65.

Reference range

Reported as negative, equivocal or positive.

Antigen Most common presentation Most frequent associated tumour
Hu, ANNA

Subacute sensory neuropathy/ encephalitis

SCLC

Yo, APCA1

Cerebellar degeneration

breast, ovary

Ri, ANNA2

Opsoclonus/myoclonus and other

breast

Ma2

Limbic encephalitis and other syndromes

testicular and other cancers

Amphiphysin

Opsoclonus, ataxia

breast, SCLC

RMP/CV2

Various

various

Tr

Cerebellar ataxia

lymphomas

Disease associations: variable.

Turnaround time

Referral lab quotes turnaround time of 6 days*, however additional time must be allowed for packing, dispatch and delivery of sample, and return and processing of results.
*40 days for anti-recoverin antibody.

Enquiries

Immunology (Referrals)

 

Details